Title : Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors.

Pub. Date : 1997 Mar

PMID : 9089421






1 Functional Relationships(s)
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1 alpha-Naphthoflavone (a CYP1A1/2 inhibitor only at concentrations < 2 mumol/L and a CYP2C9 inhibitor at higher concentrations) had a weak inhibitory effect on ethinyl estradiol formation (< 20% decrease in mestranol demethylation activity). alpha-naphthoflavone cytochrome P450 family 2 subfamily C member 9 Homo sapiens