Title : Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices.

Pub. Date : 1997 Mar 5

PMID : 9085046






5 Functional Relationships(s)
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1 Interleukin-6 increases the levels of cyclic GMP and nitrite in rat hippocampal slices. Nitrites interleukin 6 Rattus norvegicus
2 We examined the effect of interleukin-6 on the levels of cGMP and nitrite in rat hippocampal slices. Nitrites interleukin 6 Rattus norvegicus
3 In addition, exposure of slices to interleukin-6 at 80, 400 and 2000 ng/ml or at 16, 80 and 400 ng/ml for 2 h significantly elevated the cGMP level and nitrite level, respectively, in a concentration-dependent manner. Nitrites interleukin 6 Rattus norvegicus
4 However when incubated in conjunction with 400 ng/ml interleukin-6 for 2 h, NG-nitro-L-arginine apparently prevented the increase in cGMP and nitrite induced by 400 ng/ml interleukin-6. Nitrites interleukin 6 Rattus norvegicus
5 However when incubated in conjunction with 400 ng/ml interleukin-6 for 2 h, NG-nitro-L-arginine apparently prevented the increase in cGMP and nitrite induced by 400 ng/ml interleukin-6. Nitrites interleukin 6 Rattus norvegicus