Title : Protein phosphorylation changes ligand-binding efficiency of cytochrome P450c17 (CYP17) and accelerates its proteolytic degradation: putative relevance for hormonal regulation of CYP17 activity.

Pub. Date : 1997 Feb 13

PMID : 9070288






1 Functional Relationships(s)
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1 Furthermore, CYP17 degradation by cytosolic protease(s) is 2.5-fold accelerated by ATP; this action is completely reversed by the protein kinase inhibitors bisindolylmaleimide (half-maximal protective concentration 2.04 microM) and KT5720 (99 nM). Adenosine Triphosphate cytochrome P450 family 17 subfamily A member 1 Homo sapiens