Pub. Date : 1997 Mar 11
PMID : 9062121
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs. | Quinolones | Topoisomerase 2 | Drosophila melanogaster |
| 2 | Therefore, to further define interactions between drugs and the enzyme, the functional interaction domain (i.e., interaction domain defined by drug function) for quinolones on Drosophila topoisomerase II was mapped with respect to several classes of antineoplastic agents. | Quinolones | Topoisomerase 2 | Drosophila melanogaster |
| 3 | This was accomplished by characterizing the effects of ciprofloxacin (a gyrase-targeted antibacterial quinolone) on the ability of etoposide, amsacrine, genistein, and the antineoplastic quinolone, CP-115,953, to enhance topoisomerase II-mediated DNA cleavage. | Quinolones | Topoisomerase 2 | Drosophila melanogaster |