Title : Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.

Pub. Date : 1997 Feb 28

PMID : 9057869






1 Functional Relationships(s)
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1 Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such as ibuprofen, naproxen, and indomethacin were used as orally bioavailable scaffolds to design selective 5-lipoxygenase (5-LO) inhibitors. Naproxen arachidonate 5-lipoxygenase Homo sapiens