Protein Name arachidonate 5-lipoxygenase
Organism Homo sapiens
Gene ID 240
Gene Symbol

ALOX5

UniProt P09917 (LOX5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1110
Total Number of Articles : 1879
Description

arachidonate 5-lipoxygenase

Gene Summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

synonyms
  • polyunsaturated fatty acid 5-lipoxygenase
  • LOX-5
  • arachidonic acid 5-lipoxygenase
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Properties