Pub. Date : 1997 Mar 1
PMID : 9057639
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Steel factor enhances integrin-mediated tyrosine phosphorylation of focal adhesion kinase (pp125FAK) and paxillin. | Tyrosine | KIT ligand | Homo sapiens |
| 2 | SLF induced spreading of adherent TF-1 cells and enhanced tyrosine phosphorylation of pp125FAK and paxillin in a dose-dependent manner. | Tyrosine | KIT ligand | Homo sapiens |
| 3 | Wortmannin, at 10(-7) mol/L, completely abolished SLF-induced enhancement of pp125FAK tyrosine phosphorylation, while c-kit autophosphorylation was not affected. | Tyrosine | KIT ligand | Homo sapiens |
| 4 | Treatment of adherent TF-1 cells with RGDS peptide plus anti-alpha 4 antibody also inhibited SLF-induced enhancement of pp125FAK tyrosine phosphorylation without detachment of TF-1 cells. | Tyrosine | KIT ligand | Homo sapiens |
| 5 | These data suggest that SLF enhances integrin-fibronectin-dependent tyrosine phosphorylation of pp125FAK through activation of integrin ("inside-out" signaling) and following integrin occupancy. | Tyrosine | KIT ligand | Homo sapiens |