Title : Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state.

Pub. Date : 1997 Mar 4

PMID : 9054543






2 Functional Relationships(s)
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1 Disruption of the disulfide bonds of mIL-6 by treatment with iodoacetic acid (IAA-IL-6) or iodoacetamide (IAM-IL-6) reduced the biological activity, in the murine hybridoma growth factor assay, by 500- and 200-fold, respectively. Iodoacetamide interleukin 6 Mus musculus
2 Disruption of the disulfide bonds of mIL-6 by treatment with iodoacetic acid (IAA-IL-6) or iodoacetamide (IAM-IL-6) reduced the biological activity, in the murine hybridoma growth factor assay, by 500- and 200-fold, respectively. Iodoacetamide interleukin 6 Mus musculus