Title : Selective activation of caspases during apoptotic induction in HL-60 cells. Effects Of a tetrapeptide inhibitor.

Pub. Date : 1997 Mar 14

PMID : 9054391






2 Functional Relationships(s)
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1 Pretreatment of the cells with benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethylketone (zVAD.fmk), a tetrapeptide inhibitor of caspases, prevented the induction of apoptosis for 24 h. Even after 72 h of treatment, some cells were still alive and progressing through the cell cycle, suggesting that blockage of caspase activity is able to protect cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 1 Homo sapiens
2 Pretreatment of the cells with benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethylketone (zVAD.fmk), a tetrapeptide inhibitor of caspases, prevented the induction of apoptosis for 24 h. Even after 72 h of treatment, some cells were still alive and progressing through the cell cycle, suggesting that blockage of caspase activity is able to protect cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 1 Homo sapiens