Title : Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat.

Pub. Date : 1996 Mar

PMID : 9053810






1 Functional Relationships(s)
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1 We tested the hypotheses that (1) 6 h of hyperammonemia (500-600 microM) is adequate for producing astrocyte enlargement, and (2) astrocyte enlargement is attenuated by inhibition of glutamine synthetase with methionine sulfoximine. Methionine Sulfoximine glutamate-ammonia ligase Rattus norvegicus