Title : E-selectin gene expression in vascular smooth muscle cells. Evidence for a tissue-specific repressor protein.

Pub. Date : 1997 Mar

PMID : 9048649






2 Functional Relationships(s)
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1 Induction of E-selectin mRNA by lipopolysaccharide or TNF-alpha in cycloheximide-treated HASMCs was inhibited by the antioxidant pyrrolidinedithiocarbamate and the serine protease inhibitor N alpha-L-tosyl-L-phenylalanine chloromethyl ketone, suggesting that a nuclear factor-kappa B-like mechanism may play an important role in E-selectin gene expression in HASMCs. pyrrolidine dithiocarbamic acid selectin E Homo sapiens
2 Induction of E-selectin mRNA by lipopolysaccharide or TNF-alpha in cycloheximide-treated HASMCs was inhibited by the antioxidant pyrrolidinedithiocarbamate and the serine protease inhibitor N alpha-L-tosyl-L-phenylalanine chloromethyl ketone, suggesting that a nuclear factor-kappa B-like mechanism may play an important role in E-selectin gene expression in HASMCs. pyrrolidine dithiocarbamic acid selectin E Homo sapiens