Title : Divalent ion effects and insights into the catalytic mechanism of protein tyrosine kinase Csk.

Pub. Date : 1997 Feb 18

PMID : 9048573






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Csk (C-terminal Src kinase) is a protein tyrosine kinase which catalyzes the transfer of the gamma-phosphoryl group of ATP to the tyrosine hydroxyl of proteins in the presence of a divalent ion. Adenosine Triphosphate C-terminal Src kinase Homo sapiens
2 Csk (C-terminal Src kinase) is a protein tyrosine kinase which catalyzes the transfer of the gamma-phosphoryl group of ATP to the tyrosine hydroxyl of proteins in the presence of a divalent ion. Adenosine Triphosphate C-terminal Src kinase Homo sapiens
3 Steady-state kinetic analyses of Csk reactions with Co and Ni in addition to Mg and Mn on wild-type and D314E Csk with ATP and ATP gamma S [adenosine 5"-O-(3-thiotriphosphate)] as substrates were performed. Adenosine Triphosphate C-terminal Src kinase Homo sapiens
4 Steady-state kinetic analyses of Csk reactions with Co and Ni in addition to Mg and Mn on wild-type and D314E Csk with ATP and ATP gamma S [adenosine 5"-O-(3-thiotriphosphate)] as substrates were performed. Adenosine Triphosphate C-terminal Src kinase Homo sapiens
5 The Kcat thio effects [Kcat(ATP)/Kcat(ATP gamma S)] were inversely correlated with metal thiophilicity in both wild-type and D314E mutant Csk reactions, although the relationship was less pronounced in the latter. Adenosine Triphosphate C-terminal Src kinase Homo sapiens
6 The Kcat thio effects [Kcat(ATP)/Kcat(ATP gamma S)] were inversely correlated with metal thiophilicity in both wild-type and D314E mutant Csk reactions, although the relationship was less pronounced in the latter. Adenosine Triphosphate C-terminal Src kinase Homo sapiens