Title : Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.

Pub. Date : 1997 Feb 18

PMID : 9048568






1 Functional Relationships(s)
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1 In PGHS-1, cyclooxygenase inhibition by tyrosine nitration with TNM or by active site ligands leads to generation of a narrow EPR instead of a wide EPR, with both signals originating from authentic tyrosyl radicals, indicating that the hydroperoxide-induced radicals in PGHS-2 are also tyrosyl radicals. Tetranitromethane prostaglandin-endoperoxide synthase 1 Homo sapiens