Title : Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme within renal tissue.

Pub. Date : 1997 Jan

PMID : 9029719






4 Functional Relationships(s)
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1 Deficiency of the 11 beta-HSD2 isoform, as described in the syndrome of apparent mineralocorticoid excess and following liquorice (glycyrrhetinic acid) or carbenoxolone ingestion, results in hypertension in which cortisol acts as a potent mineralocorticoid. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
2 Several studies have addressed the effects of progesterone, glycyrrhetinic acid, and their derivatives on 11 beta-HSD activity, but these were largely undertaken before the characterization of the 11 beta-HSD isoforms. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
3 The dehydrogenase activity of 11 beta-HSD2 was inhibited 11 alpha-hydroxyprogesterone = 11 beta-hydroxyprogesterone > glycyrrhetinic acid > carbenoxolone = progesterone. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
4 The dehydrogenase activity of 11 beta-HSD2 was inhibited 11 alpha-hydroxyprogesterone = 11 beta-hydroxyprogesterone > glycyrrhetinic acid > carbenoxolone = progesterone. Glycyrrhetinic Acid hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens