Title : Effects of hypoxia on growth factor expression in the rat kidney in vivo.

Pub. Date : 1997 Feb

PMID : 9027719






2 Functional Relationships(s)
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1 There is accumulating evidence from in vitro studies suggesting that the genes of endothelin-1, PDGF, and VEGF are, like the erythropoietin gene, regulated by oxygen tension and by divalent cations. Oxygen endothelin 1 Rattus norvegicus
2 Hypoxia (8% O2) for six hours caused a 55-fold/1.6-fold increase of renal erythropoietin/endothelin-1 gene expression, whereas endothelin-3, PDGF-A, PDGF-B, and VEGF gene expression was unchanged. Oxygen endothelin 1 Rattus norvegicus