Pub. Date : 1997 Jan 9
PMID : 9027379
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suramin disrupts insulin-like growth factor-II (IGF-II) mediated autocrine growth in human SH-SY5Y neuroblastoma cells. | Suramin | insulin like growth factor 2 | Homo sapiens |
| 2 | Suramin prevented IGF-II-stimulated IGF-IR tyrosine phosphorylation. | Suramin | insulin like growth factor 2 | Homo sapiens |
| 3 | These results indicate that in SH-SY5Y cells, suramin acts as a cytostatic agent and can block IGF-II-dependent cell growth by preventing IGF-IR activation. | Suramin | insulin like growth factor 2 | Homo sapiens |