Pub. Date : 1997 Jan 15
PMID : 9020887
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. | 4-aminobenzhydrazide | myeloperoxidase | Homo sapiens |
| 2 | In this investigation we show that, in the presence of hydrogen peroxide, ABAH irreversibly inactivates myeloperoxidase. | 4-aminobenzhydrazide | myeloperoxidase | Homo sapiens |
| 3 | ABAH was oxidized by myeloperoxidase, and kinetic analysis of the inactivation conformed to that for a mechanism-based inhibitor. | 4-aminobenzhydrazide | myeloperoxidase | Homo sapiens |
| 4 | In the presence of oxygen, ABAH and hydrogen peroxide initially converted myeloperoxidase into compound III, which subsequently lost haem absorbance. | 4-aminobenzhydrazide | myeloperoxidase | Homo sapiens |
| 5 | We propose that myeloperoxidase oxidizes ABAH to a radical that reduces the enzyme to its ferrous intermediate. | 4-aminobenzhydrazide | myeloperoxidase | Homo sapiens |