Title : The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.

Pub. Date : 1997 Feb 1

PMID : 9012462






1 Functional Relationships(s)
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1 Here, we report that the mutation Cys-620 --> Tyr is able to cause a constitutive dimerization of Ret, with consequent activation of its kinase and transforming activities, to a lower extent than mutation of Cys-634. Tyrosine ret proto-oncogene Homo sapiens