Title : Positive and negative elements contribute to the cell-specific expression of the rat dopamine beta-hydroxylase gene.

Pub. Date : 1996 Feb

PMID : 9011768






4 Functional Relationships(s)
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1 The region between -133 and -173, which contains a consensus cyclic AMP response element (CRE), was also found to be responsive to cAMP in both DBH-expressing and non-expressing cells. Cyclic AMP dopamine beta-hydroxylase Rattus norvegicus
2 The region between -133 and -173, which contains a consensus cyclic AMP response element (CRE), was also found to be responsive to cAMP in both DBH-expressing and non-expressing cells. Cyclic AMP dopamine beta-hydroxylase Rattus norvegicus
3 DNA binding assays using antibodies to CRE binding protein-related transcription factors identified ATF-1 binding to the rat DBH-CRE, and further suggest that inhibition of cAMP regulation may be due to inhibition of ATF-1 binding by an additional factor, which binds to the DBH promoter immediately upstream of the CRE. Cyclic AMP dopamine beta-hydroxylase Rattus norvegicus
4 DNA binding assays using antibodies to CRE binding protein-related transcription factors identified ATF-1 binding to the rat DBH-CRE, and further suggest that inhibition of cAMP regulation may be due to inhibition of ATF-1 binding by an additional factor, which binds to the DBH promoter immediately upstream of the CRE. Cyclic AMP dopamine beta-hydroxylase Rattus norvegicus