Pub. Date : 1997 Jan 2
PMID : 9000514
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of Ser-1275 and Ser-1309 as autophosphorylation sites of the insulin receptor. | Serine | insulin receptor | Homo sapiens |
| 2 | Identification of Ser-1275 and Ser-1309 as autophosphorylation sites of the insulin receptor. | Serine | insulin receptor | Homo sapiens |
| 3 | We have identified Ser-1275 and Ser-1309 as novel serine autophosphorylation sites by direct sequencing of HPLC-purified tryptic phosphopeptides of the histidine-tagged insulin receptor kinase IRKD-HIS. | Serine | insulin receptor | Homo sapiens |
| 4 | We have identified Ser-1275 and Ser-1309 as novel serine autophosphorylation sites by direct sequencing of HPLC-purified tryptic phosphopeptides of the histidine-tagged insulin receptor kinase IRKD-HIS. | Serine | insulin receptor | Homo sapiens |
| 5 | We have identified Ser-1275 and Ser-1309 as novel serine autophosphorylation sites by direct sequencing of HPLC-purified tryptic phosphopeptides of the histidine-tagged insulin receptor kinase IRKD-HIS. | Serine | insulin receptor | Homo sapiens |
| 6 | The corresponding peptides (Ser-1275, amino acids 1272-1292; Ser-1309, amino acids 1305-1313) have been detected in the HPLC profiles of both the soluble kinase IRKD, which contains the entire cytoplasmic domain of the insulin receptor beta-subunit, and the insulin receptor purified from human placenta. | Serine | insulin receptor | Homo sapiens |
| 7 | The corresponding peptides (Ser-1275, amino acids 1272-1292; Ser-1309, amino acids 1305-1313) have been detected in the HPLC profiles of both the soluble kinase IRKD, which contains the entire cytoplasmic domain of the insulin receptor beta-subunit, and the insulin receptor purified from human placenta. | Serine | insulin receptor | Homo sapiens |
| 8 | In contrast, a kinase negative mutant, IRKD-K1018A, did not undergo phosphorylation at either the tyrosine or serine residues, strongly suggesting that insulin receptor kinase has an intrinsic activity to autophosphorylate serine residues. | Serine | insulin receptor | Homo sapiens |