Pub. Date : 1997 Jan 17
PMID : 8999842
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 2 | We have therefore studied the regulation of carnitine palmitoyltransferase I (CPT I) gene expression by fatty acids in the pancreatic beta-cell line INS-1 since this enzyme catalyzes the limiting step of fatty acid oxidation in various tissues. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 3 | We have therefore studied the regulation of carnitine palmitoyltransferase I (CPT I) gene expression by fatty acids in the pancreatic beta-cell line INS-1 since this enzyme catalyzes the limiting step of fatty acid oxidation in various tissues. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 4 | We have therefore studied the regulation of carnitine palmitoyltransferase I (CPT I) gene expression by fatty acids in the pancreatic beta-cell line INS-1 since this enzyme catalyzes the limiting step of fatty acid oxidation in various tissues. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 5 | We have therefore studied the regulation of carnitine palmitoyltransferase I (CPT I) gene expression by fatty acids in the pancreatic beta-cell line INS-1 since this enzyme catalyzes the limiting step of fatty acid oxidation in various tissues. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 6 | It was detectable after 1 h and reached a maximum after 3 h. The induction of CPT I mRNA by fatty acids did not require their oxidation, and 2-bromopalmitate, a nonoxidizable fatty acid, increased CPT I mRNA to the same extent as palmitate. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 7 | It was detectable after 1 h and reached a maximum after 3 h. The induction of CPT I mRNA by fatty acids did not require their oxidation, and 2-bromopalmitate, a nonoxidizable fatty acid, increased CPT I mRNA to the same extent as palmitate. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 8 | The half-life of the CPT I transcript was unchanged by fatty acids, and nuclear run-on analysis showed a rapid (less than 45 min) and pronounced transcriptional activation of the CPT I gene by fatty acids. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |
| 9 | The results indicate that the CPT I gene is an early response gene induced by fatty acids at the transcriptional level in beta- (INS-1) cells. | Fatty Acids | carnitine palmitoyltransferase 1B | Rattus norvegicus |