Title : Vascular endothelin-1 gene expression and effect on blood pressure of chronic ETA endothelin receptor antagonism after nitric oxide synthase inhibition with L-NAME in normal rats.

Pub. Date : 1997 Jan 7

PMID : 8994442






4 Functional Relationships(s)
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1 Vascular endothelin-1 gene expression and effect on blood pressure of chronic ETA endothelin receptor antagonism after nitric oxide synthase inhibition with L-NAME in normal rats. NG-Nitroarginine Methyl Ester endothelin 1 Rattus norvegicus
2 Because in rats, inhibition of NO synthase with the L-arginine analogue N omega-nitro-L-arginine methyl ester (L-NAME) induces blood pressure elevation associated with little cardiovascular hypertrophy, we studied vascular endothelin-1 gene expression in L-NAME-treated rats and the effects of chronic endothelin antagonism. NG-Nitroarginine Methyl Ester endothelin 1 Rattus norvegicus
3 Because in rats, inhibition of NO synthase with the L-arginine analogue N omega-nitro-L-arginine methyl ester (L-NAME) induces blood pressure elevation associated with little cardiovascular hypertrophy, we studied vascular endothelin-1 gene expression in L-NAME-treated rats and the effects of chronic endothelin antagonism. NG-Nitroarginine Methyl Ester endothelin 1 Rattus norvegicus
4 By Northern blot analysis, endothelin-1 mRNA levels were similar in aortas and mesenteric arteries of control and L-NAME-treated rats. NG-Nitroarginine Methyl Ester endothelin 1 Rattus norvegicus