Pub. Date : 1997 Jan 15
PMID : 8993023
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
2 | O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
3 | We have previously demonstrated that transplantation of murine bone marrow cells transduced with a recombinant retroviral vector expressing MGMT via the human phosphoglycerate kinase promoter (PGK-MGMT) protects animals in vivo from acute myelotoxicity associated with CNU treatment. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
4 | Thus, long term immunodeficiency following CNU therapy may be prevented by genetic modification of murine hemopoietic stem cells with MGMT, leading to significant improvement in post-transplant immune function. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |