Title : Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA.

Pub. Date : 1997 Jan 15

PMID : 8993023






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus
2 O6-Methylguanine DNA methyltransferase (MGMT) removes alkyl groups from the O6 position of guanine and has been shown to repair CNU-induced DNA damage. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus
3 We have previously demonstrated that transplantation of murine bone marrow cells transduced with a recombinant retroviral vector expressing MGMT via the human phosphoglycerate kinase promoter (PGK-MGMT) protects animals in vivo from acute myelotoxicity associated with CNU treatment. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus
4 Thus, long term immunodeficiency following CNU therapy may be prevented by genetic modification of murine hemopoietic stem cells with MGMT, leading to significant improvement in post-transplant immune function. 1-(2-chloroethyl)-1-nitrosourea O-6-methylguanine-DNA methyltransferase Mus musculus