Title : Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells: role of protein kinase C.

Pub. Date : 1996 Dec 24

PMID : 8954984






3 Functional Relationships(s)
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1 Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells: role of protein kinase C. We studied the modulation of the inducible nitric oxide synthase (iNOS) in cultured rat smooth muscle cells using high concentrations of glucose. Glucose nitric oxide synthase 2 Rattus norvegicus
2 Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells: role of protein kinase C. We studied the modulation of the inducible nitric oxide synthase (iNOS) in cultured rat smooth muscle cells using high concentrations of glucose. Glucose nitric oxide synthase 2 Rattus norvegicus
3 These findings suggest that high glucose in combination with stimulation by IL-1beta decreases iNOS expression and nitric oxide production, and protein kinase C activation may be playing a role in the inhibition of nitric oxide production by high glucose. Glucose nitric oxide synthase 2 Rattus norvegicus