Title : Enhancement of leishmanicidal activity of human macrophages against Leishmania major and Leishmania donovani infection using recombinant human granulocyte macrophage colony stimulating factor.

Pub. Date : 1996 Sep

PMID : 8946701






3 Functional Relationships(s)
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1 The in vitro effect of recombinant human Granulocyte Macrophage Colony Stimulating Factor (rh-GMCSF) on the leishmanicidal activity and superoxide anion productivity of macrophages derived from human blood monocytes (MOs) were investigated. Superoxides colony stimulating factor 2 Homo sapiens
2 The priming effect of rh-GMCSF on superoxide anion production by human MOs stimulated with phorbol myristate acetate (PMA) was both dose-dependent and time-dependent. Superoxides colony stimulating factor 2 Homo sapiens
3 In 72 hour-old human MOs, the maximum superoxide anion release was generated by MOs primed for 45 min with 500 U/mL of rh-GMCSF. Superoxides colony stimulating factor 2 Homo sapiens