Title : Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production.

Pub. Date : 1996 Nov

PMID : 8945918






2 Functional Relationships(s)
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1 LPS induced the formation of both inducible NOS (iNOS) and arginase, and this was accompanied by increased production of NO, citrulline, and urea. Citrulline nitric oxide synthase 2 Rattus norvegicus
2 Induction of large amounts of iNOS by LPS plus several cytokines resulted in large quantities of NO, citrulline, and NG-hydroxy-L-arginine (NOHA), but urea production was markedly diminished. Citrulline nitric oxide synthase 2 Rattus norvegicus