Title : Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9.

Pub. Date : 1996 Nov 1

PMID : 8944768






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Specific-covalent binding of tienilic acid metabolites to cytochrome P-450 (incubations in the presence of 5 mM glutathione) was markedly higher upon tienilic acid oxidation by CYP 2C9 than by CYP 2C18 and CYP 2C8. Glutathione cytochrome P450 family 2 subfamily C member 18 Homo sapiens