Title : Regulation of 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells.

Pub. Date : 1996 Sep

PMID : 8943800






2 Functional Relationships(s)
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1 Treatment with forskolin resulted in a dramatic increase in both cortisol and dehydroepiandrosterone (DHEA) secretion together with increases in expression of 3 beta-HSD and P450c17 as measured at the level of mRNA and activity. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Cotreatment with forskolin and All, however, resulted in a dose-dependent reduction in cortisol and DHEA secretion concomitant with a marked attenuation of 3 beta-HSD and P450c17 expression. Colforsin cytochrome P450 family 17 subfamily A member 1 Homo sapiens