Title : X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition.

Pub. Date : 1996 Nov 22

PMID : 8939944






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The binding geometry is characterized primarily by two interaction sites: the naphthamidine group is fixed in the S1 pocket by a typical salt bridge to Asp-189, while the pyrrolidine ring binds in the unique aryl-binding site (S4) of fXa. Aspartic Acid coagulation factor X Homo sapiens