Title : Inherited mutations within the calcium-binding sites of the integrin alpha IIb subunit (platelet glycoprotein IIb). Effects of the amino acid side chain and the amino acid position on cation binding.

Pub. Date : 1996 Aug 15

PMID : 8925838






1 Functional Relationships(s)
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1 Replacement of the highly conserved Gly418 residue, located within the flanking region of the fourth Ca(2+)-binding domain of GPIIb, with a negatively charged Asp residue resulted in marked reduction in the ability to bind divalent cations. Aspartic Acid integrin subunit alpha 2b Homo sapiens