Protein Name integrin subunit alpha 2b
Organism Homo sapiens
Gene ID 3674
Gene Symbol


UniProt P08514 (ITA2B_HUMAN)
Relationships Total Number of functionally related compound(s) : 548
Total Number of Articles : 977

integrin subunit alpha 2b

Gene Summary

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]

  • integrin alpha-IIb
  • GPalpha IIb
  • alphaIIb protein
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