| Protein Name | integrin subunit alpha 2b |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3674 |
| Gene Symbol | ITGA2B |
| UniProt | P08514 (ITA2B_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
548
Total Number of Articles : 977 |
Description |
integrin subunit alpha 2b |
| Gene Summary |
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016] |
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