Title : Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.

Pub. Date : 1996 Nov 8

PMID : 8917645






1 Functional Relationships(s)
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1 Consequently, it is proposed that the metabolism of the phosphoramidate diesters of FUdR in proliferating tissue proceeds through two separate enzymatic steps involving P-N bond cleavage by an unknown phosphoramidase followed by P-O bond cleavage by phosphatases such as 5"-nucleotidase. phosphoramidic acid 5' nucleotidase, ecto Mus musculus