Pub. Date : 1996 Nov
PMID : 8913350
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1 receptor (NK-1R) mRNA levels in the dorsal horn of the spinal cord. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |
| 2 | Dilute formalin injected into the rat hindpaw as a nociceptive stimulus increases neurokinin-1 receptor (NK-1R) mRNA levels in the dorsal horn of the spinal cord. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |
| 3 | In formalin-treated animals, the temporal pattern of peak pre-mRNA levels compared with mature mRNA indicated that chemogenic nociception either activates transcription of the NK-1R gene or decreases the rate of pre-mRNA splicing. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |
| 4 | In the ipsilateral lumbar dorsal hom, NK-1R mRNA levels were significantly increased at 2 and 6 hr after formalin injection. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |
| 5 | Levels of the NK-1R pre-mRNA containing both introns A and B were significantly increased 1 hr after formalin treatment, and levels of NK-1R pre-mRNAs containing intron A were significantly elevated at 2 hr after formalin treatment. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |
| 6 | Levels of the NK-1R pre-mRNA containing both introns A and B were significantly increased 1 hr after formalin treatment, and levels of NK-1R pre-mRNAs containing intron A were significantly elevated at 2 hr after formalin treatment. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |
| 7 | Pretreatment with LY306,740 (but not LY307,679) completely blocked the formalin-induced increase in dorsal horn NK-1R mRNA levels and significantly reduced formalin-induced behavioral activity. | Formaldehyde | tachykinin receptor 1 | Rattus norvegicus |