Title : Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulation.

Pub. Date : 1996 Oct

PMID : 8909998






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The decrease in mucin sialylation was achieved through the in situ beta-galactosylation of GalNAc alpha-O-benzyl into Gal beta 1-3GalNAc alpha-O-benzyl, which acts as a competitive substrate of Gal beta 1-3GalNAc alpha 2,3-sialyltransferase, as shown by the intracellular accumulation of NeuAc alpha 2-3Gal beta 1-3GalNAc alpha-O-benzyl in treated cells. N-acetylgalactosaminuronic acid ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Homo sapiens