Title : Oncogenic activation of the tyrosine kinase domain of the human trk proto-oncogene by fusion to a cell adhesion molecule.

Pub. Date : 1996 Oct 17

PMID : 8895522






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The 76 kDa protein product of the chimeric gene, designated bgt-trk, has been identified in NIH3T3 cells transfected with cosmid 19/2 or with bgt-trk cDNA expression constructs, and its phosphorylation in tyrosine has been found to increase when the transfected cells were seeded on plates coated with ECM components which also elicited foci formation in NIH3T3 transformation assays. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus