Pub. Date : 1996
PMID : 8880055
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. | Fluvoxamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | OBJECTIVE: The purpose of this pharmacokinetic study was to investigate the dose-dependent inhibition of model substrates for CYP2D6, CYP2C19 and CYP1A2 by four marketed selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine and paroxetine. | Fluvoxamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | CONCLUSION: This investigation confirms that paroxetine and fluoxetine are potent inhibitors of CYP2D6, that fluvoxamine and fluoxetine are moderate inhibitors of CYP2C19 and that fluvoxamine is a potent inhibitor of CYP1A2 in humans in vivo. | Fluvoxamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |