Pub. Date : 1996 Jul
PMID : 8875677
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, both DT-diaphorase and glutathione (GSH) have been regarded as protective cellular compounds against daunorubicin cardiotoxicity, but their role in daunorubicin nephrotoxicity remains unclear. | Daunorubicin | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 2 | A significant increase of MDA concentration (2.41 vs. 1.64 p < 0.001) and DT-diaphorase activity (0.2 vs. 0.12, p < 0.001) was found in the renal tissue of daunorubicin injected rats. | Daunorubicin | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |
| 3 | The results of this study give evidence that a high dosage of daunorubicin induces lipid peroxidation in renal tissue of rats stimulating the activation of DT-diaphorase and the detoxificative depletion of GSH. | Daunorubicin | NAD(P)H quinone dehydrogenase 1 | Rattus norvegicus |