Title : In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A.

Pub. Date : 1996 Mar

PMID : 8866916






1 Functional Relationships(s)
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1 Tolbutamide metabolism to 4-hydroxy tolbutamide, form selective for CYP2C9, was competitively inhibited by clozapine and phenytoin (Ki of 31 microM and 17 microM, respectively). Tolbutamide cytochrome P450 family 2 subfamily C member 9 Homo sapiens