Title : Epidermal growth factor induces glucose storage in transgenic 3T3-L1 adipocytes overexpressing epidermal growth factor receptors.

Pub. Date : 1996 Nov

PMID : 8866569






7 Functional Relationships(s)
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1 We now report that EGF receptor (EGFR)-mediated signals can induce incorporation of glucose into glycogen and lipids in these cells. Glucose epidermal growth factor receptor Homo sapiens
2 We now report that EGF receptor (EGFR)-mediated signals can induce incorporation of glucose into glycogen and lipids in these cells. Glucose epidermal growth factor receptor Homo sapiens
3 EGFRs that lack all or part of the unique EGFR COOH-terminal tail induced glucose incorporation at levels similar to that stimulated by full-length (wild type) EGFR. Glucose epidermal growth factor receptor Homo sapiens
4 EGFRs that lack all or part of the unique EGFR COOH-terminal tail induced glucose incorporation at levels similar to that stimulated by full-length (wild type) EGFR. Glucose epidermal growth factor receptor Homo sapiens
5 Thus, domains in the COOH-terminal tail of the EGFR, which are necessary for stimulating glucose transport, are not required for signaling EGF-induced glucose storage. Glucose epidermal growth factor receptor Homo sapiens
6 EGF-induced glucose storage did not require de novo protein synthesis, suggesting that EGFR signaling uses existing pathways in the adipocytes. Glucose epidermal growth factor receptor Homo sapiens
7 These data demonstrate that signaling pathways for EGFR-mediated glucose storage and GLUT4-mediated glucose transport diverge at the receptor level. Glucose epidermal growth factor receptor Homo sapiens