Title : Inhibition of expression of the multidrug resistance-associated P-glycoprotein of by phosphorothioate and 5' cholesterol-conjugated phosphorothioate antisense oligonucleotides.

Pub. Date : 1996 Oct

PMID : 8863825






1 Functional Relationships(s)
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1 We demonstrate that phosphorothioate antisense oligonucleotides can reduce levels of MDR1 message, inhibit expression of P-glyco protein, and affect drug uptake in MDR mouse 3T3 fibroblasts. Parathion ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus