Title : Restoration of Clostridium difficile toxin-B-inhibited phospholipase D by phosphatidylinositol 4,5-bisphosphate.

Pub. Date : 1996 Sep 15

PMID : 8856074






2 Functional Relationships(s)
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1 In membranes of toxin-B-treated cells, basal and GTP[S]-stimulated PLD activities were reduced, when measured with exogenous phosphatidylcholine as enzyme substrate. Phosphatidylcholines glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Inclusion of PtdIns(4,5)P2 with phosphatidylcholine in the substrate vesicles or addition of PtdIns(4,5)P2 fully restored basal and GTP[S]-stimulated PLD activities in membranes of toxin-B-treated cells. Phosphatidylcholines glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens