Pub. Date : 1996 Oct 1
PMID : 8855260
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Membrane fusion protein synexin (annexin VII) as a Ca2+/GTP sensor in exocytotic secretion. | Guanosine Triphosphate | annexin A7 | Homo sapiens |
| 2 | Membrane fusion protein synexin (annexin VII) as a Ca2+/GTP sensor in exocytotic secretion. | Guanosine Triphosphate | annexin A7 | Homo sapiens |
| 3 | However, the calcium-dependent membrane fusion reaction driven by synexin (annexin VII) is an in vitro model for this process, which we have now found to be further activated by GTP. | Guanosine Triphosphate | annexin A7 | Homo sapiens |
| 4 | However, the calcium-dependent membrane fusion reaction driven by synexin (annexin VII) is an in vitro model for this process, which we have now found to be further activated by GTP. | Guanosine Triphosphate | annexin A7 | Homo sapiens |
| 5 | The mechanism of fusion activation depends on the unique ability of synexin to bind and hydrolyze GTP in a calcium-dependent manner, both in vitro and in vivo in streptolysin O-permeabilized chromaffin cells. | Guanosine Triphosphate | annexin A7 | Homo sapiens |
| 6 | The required [Ca2+] for GTP binding by synexin is in the range of 50-200 microM, which is known to occur at exocytotic sites in chromaffin cells, neurons, and other cell types. | Guanosine Triphosphate | annexin A7 | Homo sapiens |
| 7 | Previous immunolocalization studies place synexin at exocytotic sites in chromaffin cells, and we conclude that synexin is an atypical G protein that may be responsible for both detecting and mediating the Ca2+/GTP signal for exocytotic membrane fusion. | Guanosine Triphosphate | annexin A7 | Homo sapiens |