Title : c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

Pub. Date : 1996 Oct 10

PMID : 8849724






3 Functional Relationships(s)
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1 We report here that the proto-oncogene product c-Cbl is tyrosine-phosphorylated in a Src-dependent manner in osteoclasts, where the two proteins colocalize on some vesicular structures. Tyrosine Rous sarcoma oncogene Mus musculus
2 Furthermore, tyrosine phosphorylation of c-Cbl and the localization of c-Cbl-containing structures to the peripheral cytoskeleton are impaired in resorption-deficient c-src- OCLs, as well as in wild-type OCLs that have been treated with c-src antisense oligonucleotides. Tyrosine Rous sarcoma oncogene Mus musculus
3 Furthermore, tyrosine phosphorylation of c-Cbl and the localization of c-Cbl-containing structures to the peripheral cytoskeleton are impaired in resorption-deficient c-src- OCLs, as well as in wild-type OCLs that have been treated with c-src antisense oligonucleotides. Tyrosine Rous sarcoma oncogene Mus musculus