Title : Inhibitory effects on the DNA binding of AP-1 transcription factor to an AP-1 binding site modified by benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide diastereomers.

Pub. Date : 1996 Sep

PMID : 8824521






2 Functional Relationships(s)
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1 In this study we have specifically modified the binding site of the transcription factor AP-1 with the (+)-anti- or (-)-syn-enantiomers of BPDE, and have studied how this affects the binding of the Fos-Jun proteins. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Both (-)-syn- and (+)-anti-BPDE, giving rise to a cis- and a trans-adduct, respectively, have been used and, in both cases, the binding of AP-1 like proteins from HeLa cell nuclear extracts to the modified binding site decreased by approximately 50% as compared to controls. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens