Pub. Date : 1996 Jan
PMID : 8822088
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 treatment suppressed the accumulation of ED-1-positive cells, CD4-positive cells, CD8-positive cells, interleukin-2 (IL-2)-receptor-positive cells, leukocyte-function-associated antigen-1 (LFA-1)-positive cells and intercellular adhesion molecule-1 (ICAM-1)-expression in nephritic glomeruli. | Tacrolimus | interleukin 2 | Rattus norvegicus |
| 2 | FK506 treatment suppressed the accumulation of ED-1-positive cells, CD4-positive cells, CD8-positive cells, interleukin-2 (IL-2)-receptor-positive cells, leukocyte-function-associated antigen-1 (LFA-1)-positive cells and intercellular adhesion molecule-1 (ICAM-1)-expression in nephritic glomeruli. | Tacrolimus | interleukin 2 | Rattus norvegicus |
| 3 | On the other hand, IL-2 production from the spleen cells isolated from nephritic rats treated with FK506 was lower than that in the nephritic control rats. | Tacrolimus | interleukin 2 | Rattus norvegicus |
| 4 | These results suggest that FK506 is effective against crescentic-type anti-GBM nephritis and that the antinephritic mechanisms of FK506 is due to the inhibition of intraglomerular accumulation and activation of leukocytes through the suppression of ICAM-1 expression and IL-2 production. | Tacrolimus | interleukin 2 | Rattus norvegicus |