Pub. Date : 1996 Jul
PMID : 8807890
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 2 | RESULTS: We have shown that the human mismatch-repair protein, hMSH2, also binds specifically to DNA containing cisplatin adducts and displays selectivity for the DNA adducts of therapeutically active platinum complexes. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 3 | Moreover, hMSH2 is overexpressed in testicular and ovarian tissue; tumors in these tissues are most effectively treated by cisplatin. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 4 | CONCLUSIONS: Our results suggest a role for hMSH2 in mediating cisplatin toxicity. | Cisplatin | mutS homolog 2 | Homo sapiens |
| 5 | Alternatively, hMSH2 may shield cisplatin adducts from repair, allowing adducts to persist, thus enhancing lethality. | Cisplatin | mutS homolog 2 | Homo sapiens |