| Protein Name | mutS homolog 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4436 |
| Gene Symbol | MSH2 |
| UniProt | P43246 (MSH2_HUMAN), A0A2R8Y6P0 (A0A2R8Y6P0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
199
Total Number of Articles : 293 |
Description |
mutS homolog 2 |
| Gene Summary |
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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