Title : Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity.

Pub. Date : 1995 Dec

PMID : 8786728






2 Functional Relationships(s)
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1 Here we report that salmon calcitonin mimics the actions of rat amylin on skeletal muscle glycogen metabolism in vitro; it stimulates glycogenolysis and inhibits incorporation of radiolabeled glucose into glycogen (50% effective concentration [EC50], 0.4 +/- 0.11 nmol/L log and 8.4 +/- 0.05 nmol/L log, respectively). Glycogen islet amyloid polypeptide Rattus norvegicus
2 Here we report that salmon calcitonin mimics the actions of rat amylin on skeletal muscle glycogen metabolism in vitro; it stimulates glycogenolysis and inhibits incorporation of radiolabeled glucose into glycogen (50% effective concentration [EC50], 0.4 +/- 0.11 nmol/L log and 8.4 +/- 0.05 nmol/L log, respectively). Glycogen islet amyloid polypeptide Rattus norvegicus