Pub. Date : 1996 Aug
PMID : 8770082
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously demonstrated that two isoforms (AT1A and AT1B) of the angiotensin II (ANG II) type 1 (AT1) receptor exist in the rat kidney and are differentially regulated by a low-sodium diet. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 2 | The present experiment was designed to test the hypothesis that sodium deficiency upregulates AT1A and AT1B gene expression in the adrenal gland by activating the AT1 receptor. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 3 | We conclude that sodium deficiency increases both AT1A and AT1B gene expression and elevates the AT1 receptor density in the adrenal gland. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |
| 4 | Blockade of the binding of ANG II to the AT1 receptor by losartan prevents the increases in AT1A and AT1B mRNA expression and the AT1 receptor density induced by sodium depletion, suggesting that these changes in the adrenal gland are mediated by activation of the AT1 receptor. | Sodium | angiotensin II receptor, type 1a | Rattus norvegicus |